DUTCH Test (dried urine test for comprehensive hormones)

WHAT IS DUTCH?

DUTCH Test (dried urine test for comprehensive hormones) to help providers solve complex patient cases. DUTCH is a group of validated tests that provide a complete evaluation of sex and adrenal hormones, including metabolites. The simple and convenient at-home collection for patients, and
clinical support on every DUTCH report, puts you in the driver’s seat—allowing you to solve your patients’ most complex hormone issues.

This advanced hormone testing was developed to improve on available hormone testing options. DUTCH offers the most extensive profile of sex and adrenal hormones along with their metabolites. Additionally, the daily (diurnal) pattern of free cortisol is included, along with melatonin (6-OHMS), 8-OHdG, and nine organic acids. This unique combination of clinical information is not available by any other method.

WHY USE DUTCH?

Easy Patient Collection – Patients collect just four or five dried-urine samples over a 24-hour period. Dried samples are stable for several weeks making them convenient to ship worldwide.

Analytical and Clinical Validation – The test goes through a rigorous validation process to verify accuracy, recovery, and linearity. We pride ourselves in relentlessly pursuing the most accurate and precise techniques available for testing.
Effective HRT Monitoring – DUTCH testing was designed to be optimally effective for
most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones.

HOW DOES DUTCH COMPARE TO OTHER METHODS?

DUTCH vs. Saliva – While the free cortisol pattern in saliva has clinical value, there is a significant missing piece to surveying a patient’s HPA axis function with saliva testing – measuring cortisol metabolites. To properly characterize a patient’s cortisol status, free and metabolized cortisol should both be measured to avoid misleading results when cortisol clearance is abnormally high or low. Likewise with sex hormones, measuring estrogen and androgen metabolites gives a fuller picture for more precise clinical diagnosis of hormonal imbalances and HRT monitoring.

DUTCH vs. 24-Hour Urine – There are two primary drawbacks to 24-hour urine testing of hormones. First, the collection is cumbersome, and as many as 40% of those who collect, do so in error (Tanaka, 2002). Secondly, dysfunction in the diurnal pattern of cortisol cannot be ascertained from a 24-hour collection. Some providers add saliva for daily free cortisol. DUTCH eliminates the need for two tests.

DUTCH vs. Serum – While the most universally accepted testing method (due to the
availability of FDA-cleared analyzers that are reliable and inexpensive), serum testing
is lacking in some areas. Adrenal hormones cannot be effectively tested in serum
because free cortisol cannot be tested throughout the day. There is also a lack of
extensive metabolite testing (especially for cortisol and estrogens).

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